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Gated

By Amy Christine Parker
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Random House Books for Young Readers
  • Isbn : 0449815994
  • Pages : 352
  • Category : Young Adult Fiction
  • Reads : 954
  • File Pdf: gated.pdf

Book Summary:

A fast-paced, nerve-fraying contemporary thriller that questions loyalties and twists truths. Appearances can be deceiving. Lyla Hamilton is a loyal member of the Community. Her family was happy to be chosen by Pioneer to join such an lovely gated neighborhood. Here, life seems perfect. But after meeting Cody, an outsider boy, Lyla starts questioning Pioneer, her friends, her family--everything. And if there's one thing not allowed in the Community, it's doubt. As Pioneer cleverly manipulates his flock toward disaster, the real question is: Will Lyla follow her heart or follow Pioneer over the edge? From the outside looking in, it's hard to understand why anyone would join a cult. But Gated tells the story from the inside looking out, and from behind the gates things are not quite so simple. Amy Christine Parker's beautiful writing creates a chilling, utterly unique YA story. Perfect for fans of creepy thrillers and contemporary fiction alike. "A tense psychological thriller that will leave you gasping for breath as you race to the very last page." --Gretchen McNeil, author of Ten HelloGiggles.com, August 3, 2013: "When I found out that there was a YA book about cults, of course I had to read it. As it turns out, Amy Christine Parker’s Gated is an awesome, creepy book that reminds me of my favorite cult films while still being surprising." Starred Review, Kirkus Reviews, June 15, 2013: "Parker doesn’t pull punches, indicating a level of brutality that will appropriately disturb even as it successfully conveys Lyla’s complete entrapment in the Community. Compelling and not that distant from real-world cults that have ended in tragedy." Publishers Weekly, June 10, 2013: "Parker skillfully explores the mindset and inner workings of an apocalyptic cult, steadily building toward the inevitable moment of truth...As for the apocalypse itself, Parker keeps things suitably ambiguous, resulting in a complex, intriguing tale rooted in real-world events." School Library Journal, October 2013: "This well-plotted tale will allow readers a glimpse into the possible world of a doomsday cult...The language is accessible, making it a good choice for reluctant readers. After the last page is turned, the question will linger: 'Could I ever be deceived like this?'" Examiner.com "A well-rounded and thorough look into cults while still remaining entertaining throughout. I look forward to reading more of Parker's works in the future."

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Related Books

Astray (Gated Sequel)

By Amy Christine Parker
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Random House Books for Young Readers
  • Isbn : 0449816044
  • Pages : 352
  • Category : Young Adult Fiction
  • Reads : 480
  • File Pdf: astray.pdf

Book Summary:

This—a sequel to Gated—is a nerve-fraying contemporary young adult thriller that will make readers question loyalties as it twists truths. Her life was based on a lie. Lyla Hamilton almost died escaping the Community. In her new life, the outsiders call the Community a cult. They don’t understand how easy it was to believe. How good it felt to belong. “Normal” life—high school and dating—is harder than Lyla expected. Who should she love? Who should she hate? The Community is willing to do terrible things to bring her back to the fold. The members are still preaching Pioneer’s twisted message that the end of the world is near. Pulled in two directions and unsure which way to turn, Lyla risks everything to follow her heart, but can she uncover the Community’s plan before it’s too late? Lyla’s escape was only the beginning. Praise for Gated and Astray “A tense psychological thriller that will leave you gasping for breath as you race to the very last page.” —Gretchen McNeil, author of Ten “An awesome, creepy book that reminds me of my favorite cult films.” —HelloGiggles.com * “Parker doesn’t pull punches, indicating a level of brutality that will appropriately disturb even as it successfully conveys Lyla’s complete entrapment in the Community. Compelling and not that distant from real-world cults that have ended in tragedy.” —Kirkus Reviews, Starred “A complex, intriguing tale rooted in real-world events.” —Publishers Weekly “A good choice for reluctant readers. After the last page is turned, the question will linger: ‘Could I ever be deceived like this?’ ” —School Library Journal “A well-rounded and thorough look into cults while still remaining entertaining throughout. I look forward to reading more of Parker’s works in the future.” —Examiner.com

Gated Communities in China

By Choon-Piew Pow
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Routledge
  • Isbn : 1134020961
  • Pages : 224
  • Category : Social Science
  • Reads : 849
  • File Pdf: gated-communities-in-china.pdf

Book Summary:

Moving beyond conventional accounts of gated communities and housing segregation, this book interrogates the moral politics of urban place-making in China’s commodity housing enclaves. Drawing on fieldwork and survey conducted in Shanghai, Pow critically demonstrates how gated communities are bound up in the cultural reproduction of middle-class landscape that is entrenched in the politics of the good life – defined in terms of a highly segregated landscape secured and maintained through the territorialisation of privilege, lifestyle and private property. The study challenges the concept of gated communities as simply ‘spatial containers’ of social classes and argues that Shanghai’s gated enclaves may be more fruitfully analyzed as critical sites of and for the production and consumption of an exclusive lifestyle where nascent middle-class sensibilities and identities are being (re)presented, cultivated and lived. In the final analysis, the book addresses an overarching normative concern by examining how social-spatial differentiation and exclusion in Shanghai’s gated communities potentially disrupt, challenge and unsettle the modern ideals of urban life. By adopting a geographical moral perspective, this book illuminates the moral complexities and ambiguities of place-making in Shanghai’s increasingly polarized urban landscape. As the first book length academic study on gated communities in China, this book will appeal broadly to those with interests in Urban studies and urban social development in China.

Voltage-gated Sodium Channels: Structure, Function and Channelopathies

By Mohamed Chahine
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer
  • Isbn : 3319902849
  • Pages : 450
  • Category : Medical
  • Reads : 746
  • File Pdf: voltage-gated-sodium-channels.pdf

Book Summary:

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

The Mechanism of gated calcium Transport across Biological Membranes

By S. Tsuyoshi Ohnishi
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Elsevier
  • Isbn : 0323141463
  • Pages : 344
  • Category : Science
  • Reads : 974
  • File Pdf: the-mechanism-of-gated-calcium-transport-across-biological-membranes.pdf

Book Summary:

The Mechanism of Gated Calcium Transport Across Biological Membranes presents the proceedings of a symposium, which was an unprecedented attempt to bring together diverse groups working on various aspects of the problem of gated Ca2+ transport. A variety of tissues, from Paramecium to vertebrate, and from the cell membrane to the internal membrane system, are included. This attempt appears to have been a success as many participants felt that they learned a great deal about the phenomenon in different preparations. This book is divided into six sections, with the first focusing on gated calcium transport in various tissues. It discusses such topics as the general properties of gated calcium transport, development of calcium channels in the cleavage-arrested embryo of a certain ascidian, and calcium currents in mammalian neurons. The following sections then focus on the kinetics of gated calcium transport; the pharmacology of gated calcium transport; regulation of gated calcium transport; calcium release from fragmented SR; and calcium-induced calcium release. This book will be of interest to practitioners in the fields of pharmacology, physiology, and experimental pathology.

Voltage-Gated Ion Channels as Drug Targets

By David J. Triggle,Murali Gopalakrishnan,David Rampe,Wei Zheng
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : John Wiley & Sons
  • Isbn : 3527607749
  • Pages : 492
  • Category : Science
  • Reads : 291
  • File Pdf: voltage-gated-ion-channels-as-drug-targets.pdf

Book Summary:

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

Recurrent Neural Networks

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  • Format : Pdf, ePub, Mobi, Kindle
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  • Isbn : 3030899292
  • Pages : 121
  • Category : Technology & Engineering
  • Reads : 240
  • File Pdf: recurrent-neural-networks.pdf

Book Summary:

This textbook provides a compact but comprehensive treatment that provides analytical and design steps to recurrent neural networks from scratch. It provides a treatment of the general recurrent neural networks with principled methods for training that render the (generalized) backpropagation through time (BPTT). This author focuses on the basics and nuances of recurrent neural networks, providing technical and principled treatment of the subject, with a view toward using coding and deep learning computational frameworks, e.g., Python and Tensorflow-Keras. Recurrent neural networks are treated holistically from simple to gated architectures, adopting the technical machinery of adaptive non-convex optimization with dynamic constraints to leverage its systematic power in organizing the learning and training processes. This permits the flow of concepts and techniques that provide grounded support for design and training choices. The author’s approach enables strategic co-training of output layers, using supervised learning, and hidden layers, using unsupervised learning, to generate more efficient internal representations and accuracy performance. As a result, readers will be enabled to create designs tailoring proficient procedures for recurrent neural networks in their targeted applications.

Mechanically Gated Channels and their Regulation

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  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Science & Business Media
  • Isbn : 9400750730
  • Pages : 432
  • Category : Medical
  • Reads : 236
  • File Pdf: mechanically-gated-channels-and-their-regulation.pdf

Book Summary:

The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. In our opinion the book presents not only the latest achievements in the field but also brings the problem closer to the experts in related medical and biological sciences as well as practicing doctors. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different living organs and tissues and allows to predict changes, which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. We also hope that presenting the problem will attract more attention to it both from researchers and practitioners and will assist to efficiently introduce it into the practical medicine.

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  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : New Press, The
  • Isbn : 1620972336
  • Pages : 320
  • Category : Social Science
  • Reads : 778
  • File Pdf: fortress-europe.pdf

Book Summary:

Singled out by Foreign Affairs for its reporting on “the brutal frontiers of new Europe,” Fortress Europe is the story of how the world’s most affluent region—and history’s greatest experiment with globalization—has become an immigration war zone, where tens of thousands have died in a humanitarian crisis that has galvanized the world’s attention. Journalist Matthew Carr brings to life remarkable human dramas, based on ex- tensive interviews and firsthand reporting from the hot zones of Europe’s immigration battles, in a narrative that moves from the desperate immigrant camps at the mouth of the Channel Tunnel in Calais, France, to the chaotic Mediterranean sea, where African migrants have drowned by the thousands. Speaking with key European policy makers, police, soldiers on the front lines, immigrant rights activists, and an astonishing range of migrants themselves, Carr offers a lucid account both of the broad issues at stake in the crisis and its exorbitant human costs. The paperback edition includes a new afterword by the author, which offers an up-to-the-minute assessment of the 2015 crisis and a searing critique of Europe’s response to the new waves of refugees.

Voltage Gated Sodium Channels

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  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Science & Business Media
  • Isbn : 3642415881
  • Pages : 295
  • Category : Medical
  • Reads : 201
  • File Pdf: voltage-gated-sodium-channels.pdf

Book Summary:

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

The Gated Republic

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  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Harper Collins
  • Isbn : 9353573882
  • Pages : 304
  • Category : Political Science
  • Reads : 197
  • File Pdf: the-gated-republic.pdf

Book Summary:

Seventy years since it became a republic, India has come a long way. But it is still failing on some key fronts. Piped drinking water for all continues to be a pipe dream; homes and businesses are haunted by power outages; the lack of proper primary health care renders the poorest more vulnerable; millions of children coming out of schools lack rudimentary skills; and the security of lives and enterprises, a source of great anxiety, depends on private contractors. Indians are seceding from dependence on the government for these most basic of services and are investing in the pay-and-plug economy. They have internalized the incapacity of the state to deliver these and are opting for private providers despite the costs. But can India sustain private republics amidst public failures in a landscape scarred by social and economic fault lines? What are the possible solutions? Can government reinvent itself? The Gated Republic presents an interrogative view of the history and future of private India.

Respiratory and Cardiac Gating in PET, An Issue of PET Clinics,

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  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Elsevier Health Sciences
  • Isbn : 1455772208
  • Pages : 128
  • Category : Medical
  • Reads : 997
  • File Pdf: respiratory-and-cardiac-gating-in-pet-an-issue-of-pet-clinics.pdf

Book Summary:

The complexity of issues associated with gating studies with PET imaging are mostly unknown among practitioners of the field, which is posing a significant danger to those who undergo such studies. This is particularly true for respiratory gating examination. Topics in this issue include both basic and clinical topics, including views from radiation oncology physicians.

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  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Science & Business Media
  • Isbn : 0387329331
  • Pages : 436
  • Category : Social Science
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  • File Pdf: handbook-of-community-movements-and-local-organizations.pdf

Book Summary:

Although the way associations and the organization of local social life are intertwined is one of the oldest approaches to community study, the way citizens and residents come together informally to act and solve problems has rarely been a primary focus. Associations are central to important and developing areas of social theory and social action. This handbook takes voluntary associations as the starting point for making sense of communities. It offers a new perspective on voluntary organizations and gives an integrated, yet diverse, theoretical understanding of this important aspect of community life.

Gated Communities als neue Wohnform in Südfrankreich

By Stephan Bernhard
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : diplom.de
  • Isbn : 3832454012
  • Pages : 132
  • Category : Science
  • Reads : 686
  • File Pdf: gated-communities-als-neue-wohnform-in-südfrankreich.pdf

Book Summary:

Inhaltsangabe:Einleitung: Seit den 90er Jahren sind Gated Communities, d.h. für die Öffentlichkeit geschlossene Wohnkomplexe mit Zugangskontrolle in den Blickwinkel der Medien sowie der sozialwissenschaftlichen Forschung geraten. Schwerpunkt der Forschung und der Berichterstattung liegt dabei meist auf den US-amerikanischen Städten. Entgegen dem vermittelten Bild, dass es ich um ein rein nordamerikanisches Phänomen handelt, finden sich Gated Communities aber in zahlreichen Metropolen rund um den Globus und stellen demnach einen globalen Trend dar. Die Diplomarbeit Gated Communities als neue Wohnform in Südfrankreich beweist, dass Gated Communities ebenfalls an der Cote d Azur vorzufinden sind und zwar nicht nur vereinzelt, sondern vielmehr einen massiven Trend auf dem Immobilenmarkt darstellen. In der Arbeit liegt der Schwerpunkt auf der Erfassung und Beschreibung der französischen Typen der Gated Communities und ihrer speziellen Eigenarten. Zudem werden die Gründe des Aufkommens dieser speziellen Wohnform dargestellt und mögliche Entwicklungsszenarien dieses Immobiliensektors vorgestellt. Außerdem wird die Geschichte und heutiger Stand der Gated Communities in den U.S.A. beschrieben und ein Vergleich der geschlossenen Wohnkomplexe in den U.S.A. und in Südfrankreich vorgenommen. Inhaltsverzeichnis:Inhaltsverzeichnis: Vorwort10 1.Einleitung11 1.1Zielsetzung12 1.2Beschreibung des Forschungsablaufes13 2.Die U.S.A. als Ursprung der Gated Communities15 2.1Allgemeine Merkmale der Gated Communities15 2.1.1Physische Charakteristika15 2.1.2Verwaltung und Instandhaltung19 2.1.3Regelwerke21 2.1.4Rolle der Bauherren22 2.1.5Bewohner der Gated Communities23 2.2Typologie der Gated Communities in den U.S.A.23 2.2.1Lifestyle Communities24 2.2.2Prestige Communities24 2.2.3Security Zone Communities25 2.3Entwicklung und heutiger Stellenwert der Gated Communities25 3.Beschreibung des Untersuchungsgebietes30 3.1Abgrenzung des Untersuchungsgebietes30 3.2Bevölkerungsentwicklung und -verteilung31 3.3Entwicklung und heutiges Ausmaß der Urbanisierung36 3.4Wirtschaftsstruktur39 3.5Soziale Schichtung der Bevölkerung40 3.6Entwicklung der Kriminalität48 3.7Spezifische Problemkreise50 4.Die Wohnform der Gated Communities in Südfrankreich, Ergebnis der empirischen Untersuchungen55 4.1Typologie der Gated Communities in Südfrankreich55 4.1.1Typ 1: Wohnanlagen mit Hauptwohnsitzfunktion55 Definition Bautypen Aufkommen und [...]

Memory Systems

By Bruce Jacob,Spencer Ng,David Wang
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Morgan Kaufmann
  • Isbn : 9780080553849
  • Pages : 900
  • Category : Computers
  • Reads : 355
  • File Pdf: memory-systems.pdf

Book Summary:

Is your memory hierarchy stopping your microprocessor from performing at the high level it should be? Memory Systems: Cache, DRAM, Disk shows you how to resolve this problem. The book tells you everything you need to know about the logical design and operation, physical design and operation, performance characteristics and resulting design trade-offs, and the energy consumption of modern memory hierarchies. You learn how to to tackle the challenging optimization problems that result from the side-effects that can appear at any point in the entire hierarchy. As a result you will be able to design and emulate the entire memory hierarchy. Understand all levels of the system hierarchy -Xcache, DRAM, and disk. Evaluate the system-level effects of all design choices. Model performance and energy consumption for each component in the memory hierarchy.

Clinical Nuclear Cardiology: State of the Art and Future Directions E-Book

By Barry L. Zaret,George A. Beller
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Elsevier Health Sciences
  • Isbn : 0323085725
  • Pages : 896
  • Category : Medical
  • Reads : 529
  • File Pdf: clinical-nuclear-cardiology.pdf

Book Summary:

Clinical Nuclear Cardiology—now in its fourth edition—covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters—Digital/Fast SPECT, Imaging in Revascularized Patients, and more—this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at expertconsult.com includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text. Includes access to the fully searchable contents of the book online at expertconsult.com, along with highly illustrated case studies that let you see the problem using a variety of imaging modalities. Features 20 new chapters including Cellular Mechanisms of Tracer Uptake and Clearance; Attenuation/Scatter Corrections: Clinical Aspects; Hybrid Imaging; Digital/Fast SPECT; Imaging in Revascularized Patients; and more. Focuses on perfusion imaging in a section dedicated to this hot topic so you get all the information you need to stay current.

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By Unurjargal Nyambuu,Charles S. Tapiero
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : John Wiley & Sons
  • Isbn : 1119252687
  • Pages : 480
  • Category : Business & Economics
  • Reads : 613
  • File Pdf: globalization-gating-and-risk-finance.pdf

Book Summary:

An in-depth guide to global and risk finance based on financial models and data-based issues that confront global financial managers. Globalization, Gating, and Risk Finance offers perspectives on global risk finance in a world with economies in transition. Developed from lectures and research projects investigating the consequences of globalization and strategic approaches to fundamental economics and finance, it provides an approach based on financial models and data; it includes many case-study problems. The book departs from the traditional macroeconomic and financial approaches to global and strategic risk finance, where economic power and geopolitical issues are intermingled to create complex and forward-looking financial systems. Chapter coverage includes: Globalization: Economies in Collision; Data, Measurements, and Global Finance; Global Finance: Utility, Financial Consumption, and Asset Pricing; Macroeconomics, Foreign Exchange, and Global Finance; Foreign Exchange Models and Prices; Asia: Financial Environment and Risks; Financial Currency Pricing, Swaps, Derivatives, and Complete Markets; Credit Risk and International Debt; Globalization and Trade: A Changing World; and Compliance and Financial Regulation. Provides a framework for global financial and inclusive models, some of which are not commonly covered in other books. Considers risk management, utility, and utility-based multi-agent financial theories. Presents a theoretical framework to assist with a variety of problems ranging from derivatives and FX pricing to bond default to trade and strategic regulation. Provides detailed explanations and mathematical proofs to aid the readers’ understanding. Globalization, Gating, and Risk Finance is appropriate as a text for graduate students of global finance, general finance, financial engineering, and international economics, and for practitioners.

Conformational Changes during Potassium-Channel Gating

By Jakob Renhorn
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Linköping University Electronic Press
  • Isbn : 9176853381
  • Pages : 69
  • Category :
  • Reads : 228
  • File Pdf: conformational-changes-during-potassium-channel-gating.pdf

Book Summary:

Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. The ability to sense voltage resides in the four voltage-sensor domains (VSDs) surrounding the central ion-conducting pore. Membrane depolarization causes the inside of the membrane to become positively charged, electrostatically repelling the positively charged fourth transmembrane segment (S4), or voltage sensor, in the VSD, causing the voltage sensor to move outwards. This motion provides necessary energy to open the pore and allow ion conductivity. Prolonged channel activation leads to alterations in the selectivity filter which cease ion conductivity, in a process called slow inactivation. In this thesis, we investigated the movement of S4 during activation of the channel. We also studied the communication between the four subunits during activation as well as the communication between the pore domain and VSD during slow inactivation. We have shown that voltage sensors move approximately 12 Å outwards during activation. The positively charged amino acid residues in S4 create temporary salt bridges with negative counter-charges in the other segments of the VSD as it moves through a membrane. We have also shown that the movement of one of the four voltage sensors can affect the movement of the neighboring voltage sensors. When at least one voltage sensor has moved to an up-position, it stabilizes other voltage sensors in the up-position, increasing the energy required for the voltage sensor to return to the down position. We have also shown reciprocal communication between the pore domain and the VSDs. Alterations in the VSD or the interface between the pore and the VSD cause changes in the rate of slow inactivation. Likewise, modifications in the pore domain cause changes to the voltage-sensor movement. This indicates communication between the pore and the VSD during slow inactivation. The information from our work could be used to find new approaches when designing channel-modifying drugs for the treatment of diseases caused by increased neuronal excitability, such as chronic pain and epilepsy.

Cities of Power

By Göran Therborn
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Verso Books
  • Isbn : 1784785474
  • Pages : 416
  • Category : Philosophy
  • Reads : 672
  • File Pdf: cities-of-power.pdf

Book Summary:

Why are cities centers of power? A sociological analysis of urban politics In this brilliant, very original survey of the politics and meanings of urban landscapes, leading sociologist Göran Therborn offers a tour of the world’s major capital cities, showing how they have been shaped by national, popular, and global forces. Their stories begin with the emergence of various kinds of nation-state, each with its own special capital city problematic. In turn, radical shifts of power have impacted on these cities’ development, in popular urban reforms or movements of protest and resistance; in the rise and fall of fascism and military dictatorships; and the coming and going of Communism. Therborn also analyzes global moments of urban formation, of historical globalized nationalism, as well as the cities of current global image capitalism and their variations of skyscraping, gating, and displays of novelty. Through a global, historical lens, and with a thematic range extending from the mutations of modernist architecture to the contemporary return of urban revolutions, Therborn questions received assumptions about the source, manifestations, and reach of urban power, combining perspectives on politics, sociology, urban planning, architecture, and urban iconography. He argues that, at a time when they seem to be moving apart, there is a strong link between the city and the nation-state, and that the current globalization of cities is largely driven by the global aspirations of politicians as well as those of national and local capital. With its unique systematic overview, from Washington, D.C. and revolutionary Paris to the flamboyant twenty- first-century capital Astana in Kazakhstan, its wealth of urban observations from all the populated continents, and its sharp and multi-faceted analyses, Cities of Power forces us to rethink our urban future, as well as our historically shaped present.

New Technologies in Radiation Oncology

By Wolfgang C. Schlegel,Thomas Bortfeld,Anca Ligia Grosu
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Science & Business Media
  • Isbn : 3540299998
  • Pages : 460
  • Category : Medical
  • Reads : 775
  • File Pdf: new-technologies-in-radiation-oncology.pdf

Book Summary:

- Summarizes the state of the art in the most relevant areas of medical physics and engineering applied to radiation oncology - Covers all relevant areas of the subject in detail, including 3D imaging and image processing, 3D treatment planning, modern treatment techniques, patient positioning, and aspects of verification and quality assurance - Conveys information in a readily understandable way that will appeal to professionals and students with a medical background as well as to newcomers to radiation oncology from the field of physics

Neurobiology of Mental Illness

By Dennis S. Charney,Joseph D. Buxbaum,Pamela Sklar,Eric J. Nestler
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Oxford University Press
  • Isbn : 0199934967
  • Pages : 1504
  • Category : Medical
  • Reads : 699
  • File Pdf: neurobiology-of-mental-illness.pdf

Book Summary:

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers, doctoral students, and postdoctoral fellows the neurosciences.

Cardiac Repolarization

By Nabil El-Sherif
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Nature
  • Isbn : 3030226727
  • Pages : 354
  • Category : Medical
  • Reads : 678
  • File Pdf: cardiac-repolarization.pdf

Book Summary:

This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.

Urban Design Thinking

By Kim Dovey
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Bloomsbury Publishing
  • Isbn : 1472568044
  • Pages : 304
  • Category : Architecture
  • Reads : 323
  • File Pdf: urban-design-thinking.pdf

Book Summary:

Urban Design Thinking provides a conceptual toolkit for urban design. Bridging the gap between theory and practice, it shows how the design of our cities and urban spaces can be interpreted and informed through contemporary theories of urbanism, architecture and spatial analysis. Relating abstract ideas to real-world examples, and taking assemblage thinking as its critical framework, the book introduces an array of key theoretical principles and demonstrates how theory is central to urban design critique and practice. Thirty short chapters can be read alone or in sequence, each opening a different kind of conceptual window onto how cities work and how they are transformed through design practice. Chapters range from explorations of urban morphology, typology, meaning and place identity to particular issues such as urban design codes, informal settlements, globalization, transit and creative clusters. This book is essential reading for those engaged with the practice of urban design and planning, as well as for anyone interested in the theoretical side of urbanism, architecture, and related disciplines.

The Imperatives of Urban And Regional Planning

By Anis Ur Rahmaan
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Xlibris Corporation
  • Isbn : 1465336672
  • Pages : 792
  • Category : Architecture
  • Reads : 847
  • File Pdf: the-imperatives-of-urban-and-regional-planning.pdf

Book Summary:

This book is comprised of articles and papers that have come about after years of academic and applied research endeavors of the practitioners and academicians in the field of urban and regional development planning. Most of these articles have already been presented and deliberated in national and international conferences held in different parts of the world, namely: Indianapolis, Newcastle upon Tyne, Rome, Istanbul, Cairo, Alexandria, Vienna, Stockholm, Jeddah, Riyadh, Jubail, Islamabad, Penang, and Bandung. The concepts and case studies described in this book bring home the fact that the world is undergoing a gyrational transition. Not only are developed and developing countries getting influenced by each other and transforming due to a process of circular causation, but each of the two sets of countries are also undergoing a simultaneous internal transformation due to the differential infusion of technology and indigenous entrepreneurship. As a consequence, highly diversified urban systems are getting integrated interactively, leading to the formation of a global village and achievement of a unity in diversity!

Transduction Channels in Sensory Cells

By Stephan Frings,Jonathan Bradley
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : John Wiley & Sons
  • Isbn : 3527604979
  • Pages : 321
  • Category : Science
  • Reads : 219
  • File Pdf: transduction-channels-in-sensory-cells.pdf

Book Summary:

This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.

Boolean Circuit Rewiring

By Tak-Kei Lam,Wai-Chung Tang,Xing Wei,Yi Diao,David Yu-Liang Wu
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : John Wiley & Sons
  • Isbn : 1118750144
  • Pages : 304
  • Category : Technology & Engineering
  • Reads : 209
  • File Pdf: boolean-circuit-rewiring.pdf

Book Summary:

Demonstrates techniques which will allow rewiring rates ofover 95%, enabling adoption of deep sub-micron chips for industrialapplications Logic synthesis is an essential part of the modern digital ICdesign process in semi-conductor industry. This book discusses alogic synthesis technique called “rewiring” and itslatest technical advancement in term of rewirability. Rewiringtechnique has surfaced in academic research since 1993 and there iscurrently no book available on the market which systematically andcomprehensively discusses this rewiring technology. The authorscover logic transformation techniques with concentration onrewiring. For many decades, the effect of wiring on logicstructures has been ignored due to an ideal view of wires and theirnegligible role in the circuit performance. However intoday’s semiconductor technology wiring is the major playerin circuit performance degeneration and logic synthesis engines canbe improved to deal with this through wire-based transformations.This book introduces the automatic test pattern generation(ATPG)-based rewiring techniques, which are recently active in therealm of logic synthesis/verification of VLSI/SOC designs. Unique comprehensive coverage of semiconductor rewiringtechniques written by leading researchers in the field Provides complete coverage of rewiring from an introductory tointermediate level Rewiring is explained as a flexible technique for Boolean logicsynthesis, introducing the concept of Boolean circuittransformation and testing, with examples Readers can directly apply the described techniques toreal-world VLSI design issues Focuses on the automatic test pattern generation (ATPG) basedrewiring methods although some non-ATPG based rewiring methods suchas graph based alternative wiring (GBAW), and “set of pairsof functions to be distinguished” (SPFD) based rewiring arealso discussed A valuable resource for researchers and postgraduate students inVLSI and SoC design, as well as digital design engineers, EDAsoftware developers, and design automation experts that specializein the synthesis and optimization of logical circuits.

Stochastic Models in Reliability, Network Security and System Safety

By Quan-Lin Li,Jinting Wang,Hai-Bo Yu
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Nature
  • Isbn : 981150864X
  • Pages : 497
  • Category : Computers
  • Reads : 340
  • File Pdf: stochastic-models-in-reliability-network-security-and-system-safety.pdf

Book Summary:

This book is dedicated to Jinhua Cao on the occasion of his 80th birthday. Jinhua Cao is one of the most famous reliability theorists. His main contributions include: published over 100 influential scientific papers; published an interesting reliability book in Chinese in 1986, which has greatly influenced the reliability of education, academic research and engineering applications in China; initiated and organized Reliability Professional Society of China (the first part of Operations Research Society of China) since 1981. The high admiration that Professor Cao enjoys in the reliability community all over the world was witnessed by the enthusiastic response of each contributor in this book. The contributors are leading researchers with diverse research perspectives. The research areas of the book iclude a broad range of topics related to reliability models, queueing theory, manufacturing systems, supply chain finance, risk management, Markov decision processes, blockchain and so forth. The book consists of a brief Preface describing the main achievements of Professor Cao; followed by congratulations from Professors Way Kuo and Wei Wayne Li, and by Operations Research Society of China, and Reliability Professional Society of China; and further followed by 25 articles roughly grouped together. Most of the articles are written in a style understandable to a wide audience. This book is useful to anyone interested in recent developments in reliability, network security, system safety, and their stochastic modeling and analysis.

Polymers as Electrooptical and Photooptical Active Media

By Valery Shibaev
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Science & Business Media
  • Isbn : 3642798616
  • Pages : 211
  • Category : Technology & Engineering
  • Reads : 495
  • File Pdf: polymers-as-electrooptical-and-photooptical-active-media.pdf

Book Summary:

Polymeric materials have special advantages over other materials used for the recording, storage and retrieval of information, telecommunication transmission and visualization of images. The authors describe the synthesis, the physico-chemical behavior and the applications of these highly sensitive macromolecular systems. They discuss the most essential developments in this field. For scientists and professionals working in the field of electrooptical and photooptical polymeric materials.

Cellular and Molecular Neurobiology

By Constance Hammond
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Elsevier
  • Isbn : 0080983928
  • Pages : 493
  • Category : Science
  • Reads : 529
  • File Pdf: cellular-and-molecular-neurobiology.pdf

Book Summary:

This Second Edition, is the new, thoroughly revised edition of the established and well-respected authoritative text in the field. Cellular and Molecular Neurobiology is hypothesis driven and firmly based on numerous experiments performed by experts in the field. Seven new chapters (five new and two totally rewritten) complement and expand on the first edition and are written in a way that encourages students to ask questions. Additionally, new, groundbreaking research data on dendritic processing is presented in a very easy-to-understand format. * A presentation that is hypothesis driven and firmly based on experiment * A concise but in depth explanation of molecular properties and functions of excitable cells * Over 400 two-colour illustrations * Appendices describing neurobiological techniques

ESD Design for Analog Circuits

By Vladislav A. Vashchenko,Andrei Shibkov
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Science & Business Media
  • Isbn : 1441965653
  • Pages : 459
  • Category : Technology & Engineering
  • Reads : 746
  • File Pdf: esd-design-for-analog-circuits.pdf

Book Summary:

This Book and Simulation Software Bundle Project Dear Reader, this book project brings to you a unique study tool for ESD protection solutions used in analog-integrated circuit (IC) design. Quick-start learning is combined with in-depth understanding for the whole spectrum of cro- disciplinary knowledge required to excel in the ESD ?eld. The chapters cover technical material from elementary semiconductor structure and device levels up to complex analog circuit design examples and case studies. The book project provides two different options for learning the material. The printed material can be studied as any regular technical textbook. At the same time, another option adds parallel exercise using the trial version of a complementary commercial simulation tool with prepared simulation examples. Combination of the textbook material with numerical simulation experience presents a unique opportunity to gain a level of expertise that is hard to achieve otherwise. The book is bundled with simpli?ed trial version of commercial mixed- TM mode simulation software from Angstrom Design Automation. The DECIMM (Device Circuit Mixed-Mode) simulator tool and complementary to the book s- ulation examples can be downloaded from www.analogesd.com. The simulation examples prepared by the authors support the speci?c examples discussed across the book chapters. A key idea behind this project is to provide an opportunity to not only study the book material but also gain a much deeper understanding of the subject by direct experience through practical simulation examples.

Unsettling Cities

By John Allen,Doreen Massey,Michael Pryke
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Routledge
  • Isbn : 1134636334
  • Pages : 386
  • Category : Science
  • Reads : 651
  • File Pdf: unsettling-cities.pdf

Book Summary:

This text examines the global nature of cities - cities whose openness has shaped their dynamism and character. It explores cities as sites of movement, migration and settlement where different peoples, cultures and environments combine. Unsettling Cities explores the mix of proximity and difference that exists in the rich and diverse texture of city life. The contributors reveal the association between the changing fortunes of cities and the power and influence of global networks.

Transportome Malfunction in the Cancer Spectrum

By Christian Stock,Luis A. Pardo
  • Format : Pdf, ePub, Mobi, Kindle
  • Publisher : Springer Nature
  • Isbn : 3030909204
  • Pages : 427
  • Category : Medical
  • Reads : 740
  • File Pdf: transportome-malfunction-in-the-cancer-spectrum.pdf

Book Summary:

This is the first of three volumes in the "Ion Channels & Transporters in Tumor Biology" collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis. The authors highlight the role of the so-called transportome, which is defined by the entirety of ion transporters and ion channels. Thereby, readers will get a better understanding of the impact dysregulated ion transport has on the whole spectrum of cancer types. Cancers display deficiencies in several, sometimes interdependent members of the transportome. Clinicians will be interested in the fact that controlled expression of ion transport proteins dramatically impacts the life span of cancer patients, as shown in recent studies. These observations offer a promising outlook for biomedical scientists, as members of the transportome could be the tumor markers of tomorrow - both for diagnostic and therapeutic purposes. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.